Plant Transcription Factor Database
Previous version: v3.0
Nicotiana sylvestris
Species TF ID Description
XP_009757151.1MIKC_MADS family protein
XP_009757152.1MIKC_MADS family protein
XP_009757345.1MIKC_MADS family protein
XP_009757346.1MIKC_MADS family protein
XP_009757374.1MIKC_MADS family protein
XP_009757375.1MIKC_MADS family protein
XP_009757376.1MIKC_MADS family protein
XP_009757377.1MIKC_MADS family protein
XP_009758657.1MIKC_MADS family protein
XP_009761698.1MIKC_MADS family protein
XP_009761886.1MIKC_MADS family protein
XP_009762175.1MIKC_MADS family protein
XP_009762177.1MIKC_MADS family protein
XP_009762178.1MIKC_MADS family protein
XP_009762632.1MIKC_MADS family protein
XP_009762633.1MIKC_MADS family protein
XP_009762634.1MIKC_MADS family protein
XP_009764343.1MIKC_MADS family protein
XP_009764344.1MIKC_MADS family protein
XP_009766319.1MIKC_MADS family protein
XP_009766320.1MIKC_MADS family protein
XP_009766321.1MIKC_MADS family protein
XP_009766322.1MIKC_MADS family protein
XP_009766770.1MIKC_MADS family protein
XP_009766771.1MIKC_MADS family protein
XP_009770171.1MIKC_MADS family protein
XP_009770275.1MIKC_MADS family protein
XP_009772098.1MIKC_MADS family protein
XP_009773223.1MIKC_MADS family protein
XP_009773224.1MIKC_MADS family protein
XP_009773225.1MIKC_MADS family protein
XP_009774314.1MIKC_MADS family protein
XP_009774315.1MIKC_MADS family protein
XP_009774316.1MIKC_MADS family protein
XP_009774800.1MIKC_MADS family protein
XP_009774915.1MIKC_MADS family protein
XP_009774922.1MIKC_MADS family protein
XP_009774929.1MIKC_MADS family protein
XP_009777738.1MIKC_MADS family protein
XP_009777739.1MIKC_MADS family protein
XP_009777750.1MIKC_MADS family protein
XP_009777755.1MIKC_MADS family protein
XP_009778843.1MIKC_MADS family protein
XP_009782122.1MIKC_MADS family protein
XP_009783886.1MIKC_MADS family protein
XP_009785671.1MIKC_MADS family protein
XP_009785678.1MIKC_MADS family protein
XP_009785850.1MIKC_MADS family protein
XP_009785851.1MIKC_MADS family protein
XP_009785852.1MIKC_MADS family protein
XP_009786108.1MIKC_MADS family protein
XP_009786109.1MIKC_MADS family protein
XP_009787834.1MIKC_MADS family protein
XP_009788128.1MIKC_MADS family protein
XP_009788435.1MIKC_MADS family protein
XP_009790268.1MIKC_MADS family protein
XP_009790407.1MIKC_MADS family protein
XP_009790826.1MIKC_MADS family protein
XP_009790827.1MIKC_MADS family protein
XP_009792071.1MIKC_MADS family protein
XP_009792164.1MIKC_MADS family protein
XP_009792165.1MIKC_MADS family protein
XP_009794650.1MIKC_MADS family protein
XP_009795052.1MIKC_MADS family protein
XP_009795053.1MIKC_MADS family protein
XP_009796063.1MIKC_MADS family protein
XP_009796069.1MIKC_MADS family protein
XP_009796076.1MIKC_MADS family protein
XP_009797140.1MIKC_MADS family protein
XP_009798453.1MIKC_MADS family protein
XP_009802200.1MIKC_MADS family protein
XP_009802201.1MIKC_MADS family protein
XP_009802202.1MIKC_MADS family protein
XP_009802203.1MIKC_MADS family protein
XP_009802205.1MIKC_MADS family protein
XP_009802617.1MIKC_MADS family protein
XP_009802618.1MIKC_MADS family protein
XP_009802619.1MIKC_MADS family protein
XP_009802620.1MIKC_MADS family protein
XP_009802621.1MIKC_MADS family protein
XP_009802622.1MIKC_MADS family protein
XP_009802623.1MIKC_MADS family protein
XP_009802624.1MIKC_MADS family protein
XP_009802625.1MIKC_MADS family protein
XP_009802759.1MIKC_MADS family protein
XP_009802760.1MIKC_MADS family protein
XP_009802761.1MIKC_MADS family protein
XP_009802762.1MIKC_MADS family protein
XP_009803901.1MIKC_MADS family protein
XP_009804704.1MIKC_MADS family protein
MIKC_MADS (MIKC-type MADS) Family Introduction

The best studied plant MADS-box transcription factors are those involved in floral organ identity determination. Analysis of homeotic floral mutants resulted in the formulation of a genetic model, named the ABC model, that explains how the combined functions of three classes of genes (A, B, and C) determine the identity of the four flower organs (reviewed by Coen and Meyerowitz, 1991). Arabidopsis has two A-class genes (AP1 and AP2 [Bowman et al., 1989]), two B-class genes (PI and AP3), and a single C-class gene (AG), of which only AP2 is not a MADS-box gene. Recently, it was shown that the Arabidopsis B- and C-function genes, which control petal, stamen, and carpel development, are functionally dependent on three highly similar MADS-box genes, SEP1, SEP2, and SEP3 (Pelaz et al., 2000). Interestingly, only when mutant knockout alleles of the three SEP genes were combined in a triple sep1 sep2 sep3 mutant was loss of petal, stamen, and carpel identity observed, resulting in a flower composed of only sepals. This example shows that redundancy occurs in the MADS-box gene family, which complicates reverse genetic strategies for gene function analysis. The SHP genes provide another example of MADS-box gene redundancy. shp1 and shp2 single mutants do not exhibit any phenotypic effect, whereas in the double mutant, development of the dehiscence zone is disturbed in the fruit, resulting in a failure to release seeds (Liljegren et al., 2000)[1].

It has been proposed that there are at least 2 lineages (type I and type II) of MADS-box genes in plants, animals, and fungi. Most of the well-studied plant genes are type II genes and have three more domains than type I genes from the N to the C terminus of the protein:intervening (I) domain (~30 codons), keratin-lik e coiled-coil (K) domain (~70 codons), and Cterminal (C) domain (variable length). These genes are called the MIKC-type and are specific to plants[2].

The MADS-box is a DNA binding domain of 58 amino acids that binds DNA at consensus recognition sequences known as CArG boxes [CC(A/T)6GG] (Hayes et al., 1988; Riechmann et al., 1996b). The interaction with DNA has been studied in detail for the human and yeast MADS-box proteins thanks to the resolved crystal structures (Pellegrini et al., 1995; Santelli and Richmond, 2000). The I domain is less conserved and contributes to the specification of dimerization. The K domain is characterized by a coiled-coil structure, which facilitates the dimerization of MADS-box proteins (Davies et al., 1996; Fan et al., 1997). The C domain is the least conserved domain; in some cases, it has been shown to contain a transactivation domain or to contribute to the formation of multimeric MADS-box protein complexes (Egea-Cortines et al., 1999; Honma and Goto, 2001)[1].

1.Parenicova L, de Folter S, Kieffer M, Horner DS, Favalli C, Busscher J, Cook HE, Ingram RM, Kater MM, Davies B, Angenent GC, Colombo L.
Molecular and phylogenetic analyses of the complete MADS-box transcription factor family in Arabidopsis: new openings to the MADS world.
Plant Cell. 2003 Jul;15(7):1538-51.
PMID: 12837945
2.Nam J, dePamphilis CW, Ma H, Nei M.
Antiquity and evolution of the MADS-box gene family controlling flower development in plants.
Mol Biol Evol. 2003 Sep;20(9):1435-47. Epub 2003 May 30.
PMID: 12777513